1. Karl Ekwall is at the Karolinska Institutet, Department of Biosciences and Medical Nutrition, School of Life Sciences, University College Södertörn, Alfred Nobel's Allé 7, 141 89 Huddinge, Sweden. e-mail: karl.ekwall@sh.se

Abstract

RNA interference (RNAi) is important in directing heterochromatin assembly at centromeres in fission yeast, which is crucial for maintaining a stable genome through mitotic and meiotic divisions. In this issue, Buker et al. describe a new Argonaute siRNA chaperone (ARC) that converts duplex RNA to single-stranded RNA. This is a previously unknown step in the RNAi-directed heterochromatin-formation pathway.

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