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Nature Structural & Molecular Biology 14, 174 - 175 (2007)
doi:10.1038/nsmb0307-174
Splicing oncogenes
- Anchang Hu and Xiang-Dong Fu are in the Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093-0651, USA. e-mail: xdfu@ucsd.edu
Abstract
Karni et al. report in this issue that proteins in the SR family, which modify gene function by alternative splicing, are among the many factors that can transform mammalian cells to malignancy. These splicing proteins regulate alternative splicing of many known proto-oncogenes and tumor-suppressor genes, thereby activating them post-transcriptionally to allow cells to escape normal controls on cell growth and proliferation.
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