1. Lorenzo Corsini and Michael Sattler are at the European Molecular Biology Laboratory, Meyerhofstr. 1, D-69117 Heidelberg, Germany
2. Michael Sattler is at the GSF-Research Center for Environment and Health, Ingolstädter, Landstr. 1, 85764, Neuherberg, Gemany and Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany. e-mail: sattler@embl.de

Abstract

Histone lysine methylation has a central role in transcriptional regulation and has recently been linked to DNA damage repair. Now it has been shown that the DNA damage repair factor 53BP1 is recruited to DNA double-strand breaks by its tandem tudor domain, which specifically recognizes histone H4 dimethylated at lysine 20.

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