News and Views
Nature Structural & Molecular Biology 14, 95 - 97 (2007)
doi:10.1038/nsmb0207-95
Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?
James A Hamilton1 & Richard J Deckelbaum2
- James A. Hamilton is in the Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany St., Boston, Massachusetts 02118-2526, USA
- Richard J. Deckelbaum is in the Institute of Human Nutrition, Columbia University Medical Center, 630 W. 168th St., New York, New York 10032, USA. e-mail: jhamilt@bu.edu
Abstract
A timely study in this issue reports the high-resolution crystal structure of the human plasma protein cholesteryl ester transfer protein (CETP) with its natural lipid ligands. The crystal structure will enhance both basic research on CETP-mediated cholesterol lipid transfer and the design of new drugs that increase plasma high density lipoprotein (HDL) cholesterol.
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