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Nature Structural & Molecular Biology 14, 1124 - 1125 (2007)
doi:10.1038/nsmb1207-1124
TIRF(ing) reveals Msh2-Msh6 surfing on DNA
Manju M Hingorani1
- Manju M. Hingorani is in the Molecular Biology and Biochemistry Department, Wesleyan University, Middletown, Connecticut 06459, USA. e-mail: mhingorani@wesleyan.edu
Abstract
Faced with the thermodynamic and kinetic challenge of finding a few specific sites on DNA among millions of nonspecific sites, within a limited amount of time, what's a protein to do? Single-molecule studies show that some proteins have selected sliding on DNA as a solution.
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