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Review

Nature Structural & Molecular Biology 14, 1017–1024 (1 November 2007) | doi:10.1038/nsmb1307

Cross-regulation of histone modifications

John A Latham & Sharon Y R Dent

Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show substantial cross-regulation, providing a wealth of regulatory potential. New insights into the communication between modifications on histones have emerged in recent years. This review assesses the current understanding of cross-regulation of histone modifications and identifies future questions to be addressed in this field.