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Gene regulation through nuclear organization

Nature Structural & Molecular Biology volume 14, pages 1049–1055 (2007)Cite this article

Abstract

The nucleus is a highly heterogeneous structure, containing various 'landmarks' such as the nuclear envelope and regions of euchromatin or dense heterochromatin. At a morphological level, regions of the genome that are permissive or repressive to gene expression have been associated with these architectural features. However, gene position within the nucleus can be both a cause and a consequence of transcriptional regulation. New results indicate that the spatial distribution of genes within the nucleus contributes to transcriptional control. In some cases, position seems to ensure maximal expression of a gene. In others, it ensures a heritable state of repression or correlates with a developmentally determined program of tissue-specific gene expression. In this review, we highlight mechanistic links between gene position, repression and transcription. Recent findings suggest that architectural features have multiple functions that depend upon organization into dedicated subcompartments enriched for distinct enzymatic machinery.

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Figure 1: The proteasome and its role in nuclear pore–associated transcription events.
Figure 2: Polycomb bodies and transcription factories are organized similarly.
Figure 3: Most yeast genes are infrequently transcribed.

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Acknowledgements

We thank C. Osborne, F. Bantignies and G. Cavalli for sharing their unpublished work and for helpful discussions. H.S. and S.M.G. are supported by the Swiss National Science Foundation, the Swiss National Center of Competence in Research program 'Frontiers in Genetics' and the Novartis Research Foundation. T.S. and P.F. are supported by the Biological Sciences and Biotechnology Research Council and the Medical Research Council UK.

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  1. Tom Sexton and Heiko Schober: These authors contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK

    Tom Sexton & Peter Fraser

  2. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, CH-4058, Switzerland

    Heiko Schober & Susan M Gasser

  3. National Center of Competence in Research Frontiers in Genetics, 30 Quai Ernest Ansermet, Geneva, 1211, Switzerland

    Heiko Schober & Susan M Gasser

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Sexton, T., Schober, H., Fraser, P. et al. Gene regulation through nuclear organization. Nat Struct Mol Biol 14, 1049–1055 (2007). https://doi.org/10.1038/nsmb1324

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