1. Robert J. Klose is in the Department of Biochemistry at the University of Oxford, Oxford, OX1 3QU, UK,
   e-mail: rob.klose@bioch.ox.ac.uk
2. Yi Zhang is in the Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Centre, University of North Carolina, Chapel Hill, North Carolina, 27599-7295, USA.
   e-mail: yi_zhang@med.unc.edu

Abstract

Post-translational modification of histones can profoundly affect chromatin structure and function. The discovery that histone H3 Arg2 methylation is a widespread silencing modification that inhibits histone H3 Lys4 trimethylation extends our understanding of how active and silenced chromatin states are maintained.

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