1. Nathan J. Cobb and Witold K. Surewicz are in the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA. e-mail: witold.surewicz@case.edu

Abstract

Prion 'strains', multiple conformations of the same misfolded protein, have captured great interest because of their role in transmission of mad cow disease to humans. Prion strains have also been observed in yeast, where self-propagating protein folds are responsible for inheritable traits. Recent findings reveal an exciting new insight into the structural basis of this phenomenon.

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