1. Michael Emanuele, Daniel J. Burke and P. Todd Stukenberg are in the Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, Virginia 22908, USA. e-mail: pts7h@virginia.edu

Abstract

The central function of kinetochores is to grasp a dynamic microtubule. Structural, biochemical and cell biological approaches have converged to uncover a microtubule-binding activity within the Ndc80/HEC1 complex, providing a satisfying answer to a question that has puzzled biologists for the last century.

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