Small interfering RNAs to the rescue: blocking L1 retrotransposition
Harris S Soifer & John J Rossi
The authors are in the Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA. jrossi@coh.org or hsoifer@coh.org
Controlling the ability of retrotransposons to replicate and reinsert within the genome is important for maintaining the integrity of genetic information. For the first time, it has been shown that naturally occurring small interfering RNAs exist in human cells and derive from the L1 retrotransposon, providing evidence that RNA interference has a role in regulation of retrotransposition in humans.
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