The authors are in the Department of Molecular Medicine and the Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA. rac1@cornell.edu
The activation-deactivation cycles of G proteins underlie their key roles as molecular switches for a vast array of biological responses. A study in this issue obtains a first look at how G protein–coupled receptors activate heterotrimeric G proteins to switch on signaling pathways by inducing a specific conformational change within their subunits.
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subunits.
