Stirring the POT1: surprises in telomere protection
Carolyn M Price
The author is in the Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati College of Medicine ML0524, 231 Albert Sabin Way, Cincinnati, Ohio 45267, USA. carolyn.price@uc.edu
The main function of mouse POT1 proteins is to regulate G-overhang length, suppress telomere recombination and prevent a telomeric DNA-damage response. They are not needed to prevent G-overhang loss and have only a minor role in preventing telomere fusions.
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