Nature Structural & Molecular Biology
- 13, 665 - 667 (2006)
doi:10.1038/nsmb0806-665
Helical proteins initiate replication of DNA helicesMike O'Donnell1 & David Jeruzalmi21
Mike O'Donnell is at Rockefeller University, Howard Hughes Medical Institute, New York, New York 10021, USA
2
David Jeruzalmi is in the Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138 USA.
Correspondence should be addressed to Mike O'Donnell odonnel@mail.rockefeller.edu Replication initiators in both bacteria and eukaryotes are AAA+ proteins that bind and remodel origin DNA sequences, preparing them for chromosome duplication. Two new reports show that the bacterial DnaA and eukaryotic ORC initiators form protein helical filaments. Wrapping of origin DNA around these filaments may promote DNA unwinding and subsequent assembly of replication forks.
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. NEWS AND VIEWSLearning to unwindNature Structural & Molecular Biology News and Views (01 Sep 2005)
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