Nature Structural & Molecular Biology 13, 572 - 574 (2006)
doi:10.1038/nsmb0706-572
It takes a PHD to interpret histone methylationYi Zhang
The author is in the Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA. yi_zhang@med.unc.edu
Covalent modifications of histones play an important role in regulating chromatin structure and function, probably by serving as docking sites for effector proteins. The discovery that PHD fingers of two different proteins recognize trimethyl-Lys4 of histone H3 supports and extends this notion.
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