The Pol II initiation complex: finding a place to start
Michael Hampsey
The author is in the Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA. michael.hampsey@umdnj.edu
Yeast RNA polymerase II has been proposed to 'scan' template DNA for transcription start sites. A new study mapping promoter DNA trajectory through the preinitiation complex suggests a mechanism for how this occurs.
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