1
Charles C Query is in the Dept. of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. query@aecom.yu.edu
2
Maria M. Konarska is at The Rockefeller University, New York, New York 10021, USA. konarsk@mail.rockefeller.edu
Since the discovery of Prp16, a spliceosomal ATPase that alters the fidelity of splicing, many other ATPases associated with the spliceosome have been postulated to work similarly. The finding that Prp22, a DEAH-box ATPase, functions as a fidelity factor for the second step of splicing supports this hypothesis.
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