The authors are at the Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, US National Institutes of Health, 10/10D14 MSC 1855, Bethesda, Maryland 20892-1855 USA. joshz@helix.nih.gov
Two recent studies focusing on synaptotagmin-1's role in synaptic vesicle fusion suggest that it may be key in bringing vesicle and target membranes together and in promoting SNARE assembly. The highly positive electrostatic potential of the synaptotagmin surface could catalyze fusion.
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