The authors are in the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA. jens.lykke-andersen@colorado.edu
A recent study describes a novel mRNA-surveillance pathway called 'no-go decay' that triggers the endonucleolytic cleavage of yeast mRNAs with translation-elongation stalls. This adds to the repertoire of mRNA-decay processes in which abnormal translation may activate mRNA degradation through proteins recruited to the ribosomal A site.
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