Nature Structural & Molecular Biology 13, 192 - 193 (2006)
doi:10.1038/nsmb0306-192
tRNA genes as chromatin barriersDevyani Haldar1
& Rohinton T Kamakaka21
Devyani Haldar is at the Unit on Chromatin and Transcription, National Institute of Child Health and Human Development, US National Institutes of Health, 18 Library Dr., Bethesda, Maryland 20892, USA. 2
Rohinton T. Kamakaka is at the Department of MCD Biology, 249 Sinsheimer Labs, 1156 High Street, University of California, Santa Cruz, California 95064, USA. rohinton@biology.ucsc.edu
Chromatin barriers restrict silenced chromatin domains from invading active domains. A recent study shows that a tRNA gene functions as a barrier in Schizosaccharomyces pombe. These results, similar to previous observations in Saccharomyces cerevisiae, point toward a novel function for tRNA genes and a common mechanism of compartmentalizing and organizing eukaryotic chromatin.
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