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Brief Communication
Nature Structural & Molecular Biology 13, 179–180 (1 February 2006) | doi:10.1038/nsmb1042
Transcription promotes contraction of CAG repeat tracts in human cells
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Abstract
Induced transcription through CAG repeats in human cells increases repeat contraction |[sim]|15-fold in both confluent and proliferating cells. Repeats are stabilized against contraction by siRNA knockdown of MSH2, MSH3 or XPA, but not by knockdown of MSH6, XPC or FEN1.
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