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News and Views
Nature Structural & Molecular Biology - 13, 1049 - 1051 (2006)
doi:10.1038/nsmb1206-1049

Rhomboid intramembrane protease structures galore!

Stephen H White

Stephen H. White is in the Department of Physiology and Biophysics, University of California at Irvine, Irvine, California 92697-4560, USA. stephen.white@uci.edu

The first structures of an intramembrane serine protease reveal a catalytic His-Ser dyad in a water-filled cavity surrounded by six transmembrane helices, but just how substrate helices gain access to the dyad is controversial.

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ISSN: 1545-9993
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