Nature Structural & Molecular Biology
- 13, 1049 - 1051 (2006)
doi:10.1038/nsmb1206-1049
Rhomboid intramembrane protease structures galore!Stephen H White
Stephen H. White is in the Department of Physiology and Biophysics, University of California at Irvine, Irvine, California 92697-4560, USA. stephen.white@uci.edu
The first structures of an intramembrane serine protease reveal a catalytic His-Ser dyad in a water-filled cavity surrounded by six transmembrane helices, but just how substrate helices gain access to the dyad is controversial.
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