Danny T. Huang and Brenda A. Schulman are in the Howard Hughes Medical Institute and the Departments of Structural Biology & Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, MS #311, 332 N. Lauderdale, Memphis, Tennessee 38105, USA. brenda.schulman@stjude.org
Ubiquitin-like protein (Ubl)-specific proteases catalyze Ubl precursor processing and deconjugation. Two recent structural studies of SUMO-specific protease (SENP)–substrate complexes provide new insight into hydrolysis of the peptide bond at the C terminus of SUMO. A kinked, cis configuration for the scissile bond is crucial for proteolysis.
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