Nature Structural & Molecular Biology
- 13, 1102 - 1107 (2006)
Published online: 26 November 2006; | doi:10.1038/nsmb1174
Evidence that microRNAs are associated with translating messenger RNAs in human cells
Patricia A Maroney, Yang Yu, Jesse Fisher & Timothy W Nilsen
Center for RNA Molecular Biology and Department of Biochemistry, Case Western Reserve University School of Medicine, W127 10900 Euclid Avenue, Cleveland, Ohio 44106-4973, USA.
Correspondence should be addressed to Timothy W Nilsen twn@case.edu
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3' untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentially growing HeLa cells and found that the vast majority are associated with mRNAs in polysomes. Several lines of evidence indicate that most of these mRNAs, including a known miRNA-regulated target (KRAS mRNA), are actively being translated.
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