Rabiah M. Mayas is in the Department of Biochemistry and Molecular Biology and Jonathan P. Staley is in the Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, 60637, USA. jstaley@uchicago.edu
The DEAD-box ATPase Ded1 unwinds duplex RNA with a single-stranded overhang; however, Ded1 requires the overhang not for translocation but rather for loading onto the duplex. This surprising finding expands the mechanistic repertoire for the ubiquitous DExD/H-box family.
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