Alexander Mankin is at the Center for Pharmaceutical Biotechnology, The University of Illinois, 900 S. Ashland Ave., Rm. 3056, Chicago, Illinois 60607, USA. shura@uic.edu
Many translation initiation inhibitors block transfer RNA binding or placement in the ribosome. Structures of kasugamycin bound to the bacterial ribosome now indicate that it instead blocks proper mRNA placement.
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