The author is in the Department of Biology (Area 5), University of York, PO Box 373, York YO10 5YW, UK. jpjc1@york.ac.uk
DNA helicases unwind DNA by a number of mechanisms in which conformational change seems to be of central importance. Characterization of two -hairpins and fluorescence resonance energy transfer studies of protein-DNA interactions in the minichromosome maintenance proteins afford new insights into the molecular mechanisms of these proteins.
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