A milestone in the odyssey of higher-order chromatin structure
Christopher L Woodcock
The author is in the Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA. chris@bio.umass.edu
The recent crystal structure of tetra nucleosomes supports zigzag-based models of chromatin fiber structure. The next challenge is to understand the modulation of chromatin structure in the nucleus, characterized by variability in DNA, histones and non-histone components.
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