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Nature Structural & Molecular Biology  12, 638 - 639 (2005)
doi:10.1038/nsmb0805-638

Blocking HIV-1 virus assembly

Volker M Vogt

The author is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. vmv1@cornell.edu

Two recent papers identify the first peptide inhibitor that binds to the structural protein of HIV-1, thereby blocking assembly of both immature and mature virus-like particles in vitro. These studies open the door to a strategy for the development of new therapies against the virus.

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RESEARCH

A peptide inhibitor of HIV-1 assembly in vitro

Nature Structural & Molecular Biology Article (01 Aug 2005)

Structural organization of authentic, mature HIV-1 virions and cores

The EMBO Journal Article (01 Apr 2003)

The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor

Nature Structural & Molecular Biology Article (01 Aug 2005)

The stoichiometry of Gag protein in HIV-1

Nature Structural & Molecular Biology Article (01 Jul 2004)

Visualization of a missing link in retrovirus capsid assembly

Nature Article (05 Feb 2009)

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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