Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 12 Issue 8, August 2005

The red ribbon symbolizes the global solidarity with people living with HIV/AIDS and the commitment to fight this disease. Here, the ribbon puzzle represents the HIV capsid assembly, which is essential for the integrity of the immature and mature virus particle. Individual capsid protein dimers form the puzzle pieces. Binding of a newly identified peptide inhibitor alters the pieces such that they cannot assemble into infectious particles. The peptide is thus a lead compound for a new class of HIV drugs. pp 671-677, pp 678-682; News and Views pp 638-639.

Volume 12 Issue 8

Subscribe

Editorial

Top of page ⤴

Correspondence

Top of page ⤴

News & Views

  • Two studies now explain why triplet DNA repeats tend to expand in the human genome, causing such severe hereditary neurological disorders as myotonic dystrophy and Huntington disease.

    • Sergei M Mirkin
    News & Views

  • Two recent papers identify the first peptide inhibitor that binds to the structural protein of HIV-1, thereby blocking assembly of both immature and mature virus-like particles in vitro. These studies open the door to a strategy for the development of new therapies against the virus.

    • Volker M Vogt
    News & Views

  • The recent crystal structure of tetra nucleosomes supports zigzag-based models of chromatin fiber structure. The next challenge is to understand the modulation of chromatin structure in the nucleus, characterized by variability in DNA, histones and non-histone components.

    • Christopher L Woodcock
    News & Views
Top of page ⤴

Review Article

Top of page ⤴

Article

Top of page ⤴

Search

Advanced search

Quick links