Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Spliceosome assembly in yeast: one ChIP at a time?

Nature Structural & Molecular Biology volume 12, pages 571–573 (2005)Cite this article

When and how the spliceosome assembles on its substrates in living yeast cells has been unclear. It is now evident that the 'when' is during transcription; the 'how' remains debatable.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Nascent RNA ChIP.

References

  1. Jurica, M.S. & Moore, M.J. Mol. Cell 12, 5–14 (2003).

    Article  CAS  Google Scholar 

  2. Nilsen, T.W. Bioessays 25, 1147–1149 (2003).

    Article  Google Scholar 

  3. Lacadie, S.A. & Rosbash, M. Mol. Cell (in the press) (2005).

    Google Scholar 

  4. Görnemann, J., Kotovic, K.M., Hujer, K. & Neugebauer, K.M. Mol. Cell in the press (2005).

    Google Scholar 

  5. Stevens, S.W. et al. Mol. Cell 9, 31–44 (2002).

    Article  CAS  Google Scholar 

  6. Nilsen, T.W. Mol. Cell 9, 8–9 (2002).

    Article  CAS  Google Scholar 

  7. Zenklusen, D., Vinciguerra, P., Wyss, J.-C. & Stutz, F. Mol. Cell. Biol. 22, 8241–8253 (2002).

    Article  CAS  Google Scholar 

  8. Makarov, E.M. et al. Science 298, 2205–2208 (2002).

    Article  CAS  Google Scholar 

  9. Makarova, O.V. et al. EMBO J. 23, 2381–2391 (2004).

    Article  CAS  Google Scholar 

  10. Spingola, M., Grate, L., Haussler, D. & Ares, M. Jr., RNA 5, 221–234 (1999).

    Article  CAS  Google Scholar 

  11. Proudfoot, N.J., Furger, A. & Dye, M.J. Cell 108, 501–512 (2002).

    Article  CAS  Google Scholar 

  12. Kornblihtt, A.R., de la Mata, M., Fededa, J.P., Munoz, M.J. & Nogues, G. RNA 10, 1489–1498 (2004).

    Article  CAS  Google Scholar 

  13. Labourier, E., Adams, M.D. & Rio, D.C. Mol. Cell 8, 363–373 (2001).

    Article  CAS  Google Scholar 

  14. Paca, R.E., Hibbert, C.S., O'Sullivan, C.T. & Beemon, K.L. J. Virol. 75, 7763–7768 (2001).

    Article  CAS  Google Scholar 

  15. Wyatt, J.R., Sontheimer, E.J. & Steitz, J.A. Genes Dev. 6, 2542–2553 (1992).

    Article  CAS  Google Scholar 

  16. Maroney, P.A., Romfo, C.M. & Nilsen, T.W. Mol. Cell 6, 317–328 (2000).

    Article  CAS  Google Scholar 

  17. Das, R., Zhou, Z. & Reed, R. Mol. Cell 5, 779–787 (2000).

    Article  CAS  Google Scholar 

  18. Donmez, G., Harthuth, K. & Lührmann, R. RNA 10, 1925–1933 (2004).

    Article  Google Scholar 

  19. Staley, J.P. & Guthrie, C. Cell 92, 315–326 (1998).

    Article  CAS  Google Scholar 

  20. Wassarman, D.A. & Steitz, J.A. Science 257, 1918–1925 (1992).

    Article  CAS  Google Scholar 

  21. Johnson, T.L. & Abelson, J. Genes Dev. 15, 1957–1970 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, 44106-4973, Ohio, USA

    Timothy W Nilsen

Authors
  1. Timothy W Nilsen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nilsen, T. Spliceosome assembly in yeast: one ChIP at a time?. Nat Struct Mol Biol 12, 571–573 (2005). https://doi.org/10.1038/nsmb0705-571

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0705-571

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing