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Nature Structural & Molecular Biology  12, 392 - 393 (2005)
doi:10.1038/nsmb0505-392

Rad50 connects by hook or by crook

Michael Lichten

The author is in the Laboratory of Biochemistry, Center for Cancer Research, Building 37, Room 6124, National Cancer Institute, Bethesda, Maryland, 20892-4255, USA. lichten@helix.nih.gov

The Mre11 protein complex plays important roles in maintaining genome stability. Inter-molecular bridging by the Rad50 protein has now been shown to be critical to this complex's function.

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RESEARCH

The Rad50 hook domain is a critical determinant of Mre11 complex functions

Nature Structural & Molecular Biology Article (01 May 2005)

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Open Innovation Challenges

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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