The authors are in the Gene Expression Unit and Structural & Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany ladurner@embl.de
A new study shows that CtBP, a transcription corepressor, may mediate its effect by blocking histone acetylation, a mark of active transcription. This activity is modulated by NADH binding, thereby supporting a link between cellular metabolism and gene expression.
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