The second extracellular loop: a damper for G protein−coupled receptors?
Dominique Massotte
& Brigitte L Kieffer
The authors are at IGBMC, CNRS/INSERM/ULP, 1 rue Laurent Fries BP 10142, 67404 Illkirch Cedex, France. briki@igbmc.u-strasbg.fr
A recent study suggests a novel role for the second extracellular loop of GPCRs: it may orchestrate a network of interactions that stabilize the inactive conformation of the receptor and control the on-off transition.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
