The authors are at the Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. susang@helix.nih.gov
A noncoding regulatory RNA in Escherichia coli, SgrS, downregulates the message for the glucose transporter, limiting accumulation of toxic sugar phosphates. Now a new study finds that SgrS can work only when the target message is brought to the membrane by transmembrane coding regions.
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