The author is in the Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208040, New Haven, Connecticut 06520, USA. joann.sweasy@yale.edu
Although RecA filaments are required for genetic recombination, it now seems that they are not required for translesion synthesis and that they actually inhibit this process. This finding along with elegant biochemical studies of mutant proteins moves us closer to discerning the direct role of RecA protein in SOS mutagenesis.
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