The authors are in the Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109-1024, USA. aferre@fhcrc.org
The first structure of a ribozyme that catalyzes the stereospecific carbon-carbon bond formation between two small molecules shows how an RNA active site can perform the synthetically important Diels-Alder reaction. Surprisingly, the ribozyme active site shares structural features with proteins that catalyze the same reaction.
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