Nature Structural & Molecular Biology
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November 2005 - Vol 12 No 11
Nature Structural & Molecular Biology 12 (2005)
 
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Stem cells proliferate at one end of the C. elegans germline, and sperm differentiate at the other. FBF, a pumilio-like protein, promotes proliferation in the germline by repressing gld-1 mRNA. Opperman et al. show that FBF requires a single 'extra' nucleotide in its RNA targets, and so specifically binds gld-1 and not other RNAs. Blue is DAPI, green is a sperm marker. Images provided by S. Crittenden and J. Kimble. pp 945-951
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