The authors are at Whitehead Institute of Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. lindquist_admin@wi.mit.edu
New work places the Hsp70/DnaK system in an opening role in protein disaggregation, facilitating the extraction of individual polypeptides from the aggregate surface to the axial channel of Hsp104/ClpB. It also reinforces a long-standing belief that reactivation rather than simple clearance of aggregated protein is necessary for cell stress tolerance.
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