The author is in the Department of Cell and Developmental Biology and the North Carolina Cystic Fibrosis Research Center, The University of North Carolina, Chapel Hill, North Carolina 27599, USA. dmcyr@med.unc.edu
The deletion of residue 508 in CFTR is the most common cystic fibrosis−causing mutation. Recent studies indicate that the main chain and side chain of this residue contribute to the proper folding of CFTR at different stages.
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F508 folding
