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Nature Structural & Molecular Biology  11, 812 - 815 (2004)
Published online: 26 August 2004; | doi:10.1038/nsmb820

Combinatorial control of gene expression

Attila Reményi1, 2, 4, Hans R Schöler1, 3 & Matthias Wilmanns2

1  Gene Expression Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

2  European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, D-22603 Hamburg, Germany.

3  Max-Planck-Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Mendelstrasse 7, 48149 Münster, Germany.

4  Present address: University of California, San Francisco, Department of Cellular and Molecular Pharmacology, 600 16th Street, San Francisco, California 94143-2240, USA.

Correspondence should be addressed to Attila Reményi remenyi@itsa.ucsf.edu
Revealing the molecular principles of eukaryotic transcription factor assembly on specific DNA sites is pivotal to understanding how genes are differentially expressed. By analyzing structures of transcription factor complexes bound to specific DNA elements we demonstrate how protein and DNA regulators manage gene expression in a combinatorial fashion.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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