A view into the catalytic pocket of cyclic nucleotide phosphodiesterases
Marco Conti
The author is in the Division of Reproductive Biology of the Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA. marco.conti@stanford.edu
Cyclic nucleotide phosphodiesterases are widely expressed enzymes that function as critical components of cell signaling pathways. In a new study, key interactions in the catalytic pocket essential for substrate selectivity have been identified for these enzymes, thus introducing novel perspectives for drug design.
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