Matthew C. Whitby is in the Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. matthew.whitby@bioch.ox.ac.uk
Mus81-Eme1 is a structure-specific DNA endonuclease complex that processes DNA junctions during the recombinational repair of DNA damage. The recent observation that mice containing disruptions in one or both copies of the MUS81 gene are profoundly cancer prone demonstrates that efficient processing of recombination intermediates is necessary to guard against tumorigenesis.
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