1
T.J.B. is in the Department of Biomedical Sciences, Gen*, NY*sis Center for Excellence in Cancer Genomics, University at Albany-SUNY, Rensselaer, New York 12144, USA.
2
L.D.S. is in the Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139. lsamson@mit.edu
Structures of the human O6-alkylguanine-DNA alkyltransferase bound to substrate together with biochemical analysis provide clues to substrate acquisition and recognition, as well as details of the methyl transfer reaction catalyzed by this direct DNA repair protein.
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