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Volume 11 Issue 7, July 2004

The two hands showing the American Sign Language for the letters G and H are meant to represent the subtle differences in two highly related receptors-the dendritic and the endothelial cell receptors DC-SIGN and DC-SIGNR, respectively. Structural and mutagenesis studies provide an understanding of the molecular basis for the observed differences in ligand-binding properties and physiological functions of these two receptors. pp 591-598. Cover by Erin Boyle.

Volume 11 Issue 7

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  • Structures of the clamp loader–clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.

    • Zhihao Zhuang
    • Michelle M Spiering
    • Stephen J Benkovic
    News & Views

  • Ero1p is the primary source of disulfide bonds in eukaryotes. Its crystal structure now gives us a glimpse into the elegant dance moves that accompany the formation of disulfides.

    • James C A Bardwell
    News & Views

  • Recent structural studies of KaiA and KaiB, two bacterial biological clock proteins, mark the beginning of a new phase in the analysis of circadian clock mechanisms.

    • Carl H Johnson
    • Martin Egli
    News & Views

  • Peptide bond formation by the ribosome is central to the expression of genetic information, yet its precise mechanism has resisted elucidation for decades. Two recent studies indicate that substrate orientation is the sole driving force behind the ribosome-catalyzed reaction.

    • Steven T Gregory
    • Albert E Dahlberg
    News & Views

  • A recent study shows that the p62 subunit of the general transcription factor TFIIH contains a PH domain that interacts with a major component of the nucleotide excision repair (NER) machinery. The involvement of the PH domain in NER raises interesting questions regarding the dual role of TFIIH in transcription and DNA repair.

    • Kon Yew Kwek
    • William O'Gorman
    • Alexandre Akoulitchev
    News & Views
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