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Journal home Advance online publication Current issue Archive Press releases Supplements Focus Guide to authors Online submission Permissions For referees Free online issue Contact the journal Subscribe Advertising work@npg naturereprints About this site For librarians   NPG Resources Nature Nature Cell Biology Nature Reviews Molecular Cell Biology The EMBO Journal Nature Reports Avian Flu NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Structural & Molecular Biology  11, 580 - 581 (2004) doi:10.1038/nsmb0704-580 'Screw-cap' clamp loader proteins that thread Zhihao Zhuang1, Michelle M Spiering1, Anthony J Berdis2, Michael A Trakselis3 & Stephen J Benkovic1 1  Z.Z., M.M.S. and S.J.B. are in the Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. sjb1@psu.edu 2  A.J.B. is in the Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA. 3  M.A.T. is at the MRC Cancer Cell Unit, Hutchinson/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK. Structures of the clamp loader−clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. NEWS AND VIEWS Molecular biology The loader of the rings Nature News and Views (17 Jun 2004) A sliding clamp monkey wrench Nature Structural Biology News and Views (01 Oct 2001) RESEARCH Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice Journal of Cerebral Blood Flow & Metabolism Original Article The clamp-loading complex for processive DNA replication Nature Structural & Molecular Biology Article (01 Jul 2004) See all 13 matches for Research  Top Abstract | Next Table of contents Full text Download PDF Send to a friend Open Innovation Challenges Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... Methods of Modeling Adaptation in Populations Deadline: Dec 30 2009 Reward: $15,000 USD The analysis of adaptation with a population is a frequently encountered computational modeling scen... More Challenges Powered by: nature jobs Faculty Positions University of Texas Medical Branch Galveston, TX United States Natural Products Chemist Praj Matrix - Praj Industries Ltd Pune, Maharashtra Pune-411021 India More science jobs Post a job for free Figures & Tables See also: Article by Miyata et al. Export citation Search buyers guide:   ADVERTISEMENT

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