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Review
Nature Structural & Molecular Biology  11, 503 - 511 (2004)
Published online: 25 May 2004; | doi:10.1038/nsmb779

The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

Tobias von der Haar1, John D Gross2, Gerhard Wagner3 & John E G McCarthy1

1  Post-transcriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK.

2  Department of Biochemistry and Molecular Pharmacology, Lazare Research Building, 364 Plantation Street, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2324, USA.

3  Department of Biological Chemistry and Molecular Pharmacology, 240 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA.

Correspondence should be addressed to Tobias von der Haar Tobias.von-der-Haar@umist.ac.uk or John E G McCarthy John.McCarthy@umist.ac.uk
Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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