Helicases become mechanistically simpler and functionally more complex
Peter H von Hippel
The author is in the Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, Oregon 97403, USA. petevh@molbio.uoregon.edu
Nucleic acid helicases have classically been defined as ATP-driven proteins or protein complexes that move directionally along DNA or RNA strands to unwind nucleic acid duplexes. More recently, it has been shown that helicases can also effectively displace bound proteins from their nucleic acid 'tracks.' Three recent papers add to our knowledge of molecular mechanisms on both of these fronts.
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