Making structural sense of nonsense-mediated decay
Jens Lykke-Andersen
The author is in the Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA. Jens.Lykke-Andersen@colorado.edu
A new study reports the hUpf2-hUpf3b interaction domain structure and provides the first structural insight into the core of the nonsense-mediated decay pathway. Surprisingly, the RNA-recognition motif of hUpf3b, a domain typically involved in RNA binding, constitutes instead an interaction surface for hUpf2.
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